2019-04-25 · Allegro Ophthalmics has added ALG-1007, a new anti-integrin drug candidate for the treatment of dry eye disease, to its portfolio, the company announced in a press release.The topical agent is

ALG-1007: Promising Results in Human POC Clinical Trial Robust statistically significant efficacy with 0.6% in multiple signs and symptoms Dose response curve observed - indicating the effect is due to the active ingredient No AEs even at the highest dose No reported blurring of vision or eye irritation NASAL CONJSTAIN -MEAN CFB-1.8-1.6-1.4-1.2

ALG-1007 is a topical integrin regulator in development for potential use in patients with dry eye disease. ALG-1007 demonstrated a strong signal in an ex-U.S. proof-of-concept clinical trial in which it showed a dose-response curve and that it was generally well-tolerated. 2020-09-21 · (RTTNews) - Bausch Health Companies Inc. (BHC, BHC.TO), through its affiliate, has entered into an agreement to acquire an option to purchase all ophthalmology assets of Allegro, including global ALG-1007 is a topical treatment in development for potential use in patients with dry eye disease (DED), a condition affecting millions of people in the United States. ALG-1007 bolsters Allegro’s existing anti-integrin portfolio, which includes risuteganib (Luminate®), currently being developed for diabetic macular edema (DME) and intermediate dry age-related macular degeneration Other ophthalmology assets of Allegro include ALG-1007, a topical integrin regulator under investigation for the treatment of dry eye disease.

Alg-1007

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Objectives The objective of the study was to evaluate the safety and efficacy of ALG-1007 topical ophthalmic solution in patients with dry eye disease (DED).

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This frequently blurs vision, reading ability, and produces light sensitivity in many patients.

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Other ophthalmology assets of Allegro include ALG-1007, a topical integrin regulator under investigation for the treatment of dry eye disease. It is currently in Phase 2 development outside the United States. The Option payment totaling $50 million would be made in two tranches, with the first payment of $10 million upon signing.

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At the highest dose concentration, ALG-1007 demonstrated statistically significant efficacy in nearly all assessments and a more rapid onset of action compared with the lowest dose. ALG-1007 was well tolerated with no drug-related adverse events, and there was no reported blurring of vision or ocular irritation.

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